The most accurate and efficient monitoring device for heart rate variability

At the heart of innovation

After 23 years of research and development, MDoloris Inc has released a heart rate variability monitoring device. The HFVI technology (High frequencies variability index) can be used in any operation room for any type of surgery. It can also be used in the PACU, ICU, during opioid free anesthesia (OFA) and hypnosis. Thanks to the algorithm, the HFVI monitor can help physicians evaluate the high frequency component of the heart rate variability in all types of patients, both unconscious or conscious.

How it works




The calculation of our index relies on obtaining a series of R-R time intervals from the patient’s ECG signal.



The resulting R-R series are filtered in real-time thanks to a detection algorithm. Each R-R series is then re-sampled, isolated in a temporary window and normalized.



To finish the calculation we take all of the information extracted from the ECG and embed it into the algorithm for analysis.  That analysis allows for display of the indices and their curves..


MDoloris (, a medical devices manufacturer, was created in June 2010 out of 23 years of academic research performed in Lille University hospital, France.

It has an international representation in more than 70 countries and a scientific, technical and medical acknowledgement.
MDoloris has so far developed three products, all able to continuously assess the parasympathetic level of patients.
Its innovative technologies provide clinical added value for clinicians who are not able to communicate with their patients in order to personalize medications and avoid known side effects due to over- and under-dosage of such drugs.

More than 2200 devices are now used by anesthesiologists and intensivists wordwide and more than 200,000 patients have benefited from MDoloris’ technologies. MDoloris’s standalone monitor promoting its innovative adult technology has received 510(k) clearance through the HFVI brand in the US under the number K142969. MDoloris recently closed a nine-million euro fundraising round in order to keep developing new-to-the-world technologies that always keep one target in mind: helping clinicians improve the quality of care.
Discover MDoloris to the rest of the world


Our technology is used by top physicians around the world


“The MDoloris technology has been a very valuable tool in guiding opioid administration intraoperatively. The HFVI provides us with more information on the patient’s level of analgesia, allowing us to better administer intraoperative agents, thus reducing the amount of pain patients experience postoperatively. This is especially useful in opioid-tolerant patients, obese patients, and cases for which pain can vary significantly.”

Dr. Tiffany Moon
Professor of Anesthesiology and Pain Management at UT Southwestern Medical Center.


“I find that using HVFI during anesthesia brings additional knowledge and appreciation of what is happening to the patient during the surgery. It gives me more confidence in treating hemodynamic responses and is easy and reassuring to interpret”

Dr. Irene Osborne
Professor of Anesthesiology Albert Einstein College of Medicine

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